Page 18 - TheTalents 2018 Debate13

With silicone...less urothelial
destruction: further evidence
• Silicone causes less superficial epithelial destruction in the upper urinary tract, but it is still prone to encrustation.
• The effects of various double-J stent materials on pressure conditions in the upper urinary tract, on the urothelium, on urine precipitation (encrustation), and on urinary infection were investigated in vivo, in pig ureters, and in vitro, by cell cultures and bacterial adhesion assays
• Pure polyurethane stents were found to cause long-lasting changes of renal pelvic dynamics and, consequently, to have deleterious effects on renal function. Stents made of "modified polyurethane" were found to be cytotoxic in vitro. Silicone and Hydro-Plus stents appeared to be the safest overall, as they caused less superficial epithelial destruction and host reaction than the others
5th April 2018, Paris
Trans-Atlantic Leaders in ENdourological TechnologieS